Research is an important part of the IBD service. Our participation in research allows patients to access new treatments, and develop our understanding of IBD.

Patients with IBD may be asked to take part in research studies. This is entirely voluntary and their treatment will not be affected if they choose not to participate



A. AWARE-IBD (Chief investigator, Professor Lobo)

  • A longitudinal study, funded by the Health Foundation, to co-design service changes with patients attending the service. The aim is to put patients in control of their care.
  • We are looking for people to get involved in this study across a range of levels of involvement.


B. PoPSTER study - What are treatment preferences of people and clinicians when steroids have not worked in ulcerative colitis? (Chief investigator, Professor Lobo)

This is a study funded by the National Institute for Health Research


C. DiSCUSs study (Chief investigator, Professor Lobo)

This is a study funded by Crohn’s and Colitis UK. Using qualitative and quantitative methods to develop a decision aid for patients considering surgery for inflammatory bowel disease


D. How can we support decision making by young people with IBD? (Professor Lobo)


E. Psychological consequences of inflammatory bowel disease. (Dr Brooks, Professor Lobo and the University of Sheffield)

A pilot and feasibility randomised controlled trial of a group mindfulness and self-compassion intervention for young people diagnosed with Inflammatory Bowel Disease. This is a study funded by Crohn’s and Colitis UK


F. Why do people develop antibodies to infliximab? (Professor Lobo)

Utilising molecular immunological techniques to ascertain determinants of immunogenicity in infliximab treated patients


G. The IBD Bioresource – a national study collecting samples as a resource to investigate causes of inflammatory bowel disease (Local PI, Professor Lobo)


E. New treatments for inflammatory bowel disease

  • ASTIC-LITE trial – a randomised trial of bone marrow transplantation for refractory Crohn’s disease (Local PI, Professor Lobo) – trial now stopped
  • Alofisel – local stem cell injection for perianal Crohn’s fistulas (Local PI, Professor Lobo) – study complete
  • ACCURE – a randomised trial of appendicectomy for ulcerative colitis (Local PI, Professor Lobo)
  • PROFILE – a randomised controlled trial of more intense treatment for Crohn’s disease (Local PI, Dr Chew)
  • IASO – a randomised controlled trial of Anakinra for acute severe ulcerative colitis (Local PI, Dr Brooks) – trial now stopped